Lp(a) Drug Failure: Why Pelacarsen Didn’t Work and What’s Next
Novartis discontinues pelacarsen after Phase 3 trial showed no cardiovascular benefit. Learn why this Lp(a)-lowering drug failed and what novel RNA therapies are coming next.
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Cardiovascular Health sits under Chronic Condition Management . Heart and vascular disease: risk, diagnosis, and the evidence behind treatment.
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Novartis discontinues pelacarsen after Phase 3 trial showed no cardiovascular benefit. Learn why this Lp(a)-lowering drug failed and what novel RNA therapies are coming next.
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The 2026 ACC/AHA dyslipidemia guideline replaces the 2018 recommendations with earlier screening, new PREVENT risk equations, universal Lp(a) testing, and lower LDL-C targets for many patients.
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